Researchers presented results from a phase 2 trial of a hormonal birth control gel for men. The gel contains testosterone and Nestorone, which reduces sperm production.
In the trial of 222 men who applied the gel daily, 86% achieved effective sperm suppression (less than 1 million sperm/mL) after 12 weeks. The average time to effectiveness was 8 weeks.
This is faster than past attempts and requires less testosterone than using testosterone alone, due to the addition of Nestorone. Few side effects were reported beyond some acne and possible weight gain.
The gel is the most advanced male contraceptive in clinical trials but larger, longer phase 3 trials are still needed and not yet funded.
Several other male contraceptive approaches are also in development, including a non-hormonal pill and a gel intended to block the vas deferens.
Surveys find significant interest among men in new contraceptive options, though funding has been a major barrier to progressing male methods through clinical trials.
Wider approval and adoption of male contraceptives could depend on greater recognition of demand and companies investing in later-stage trials.
Source: NBC News
